Inflammatory bowel disease attacks quickly and makes patients miserable. Recently, British researchers found the key factors causing inflammatory bowel disease. Now let's take a look at the key factors caused by inflammatory bowel disease!
Nedavno je britanski istraživački tim otkrio da protein nazvan T-bet igra važnu ulogu u održavanju osjetljive ravnoteže između crijevnog imunološkog sustava i crijevne flore. Eksperimenti pokazuju da brisanje ovog proteina može dovesti do simptoma sličnih ljudskoj upalnoj bolesti crijeva (IBD) kod miševa. Stoga znanstvenici vjeruju da se način na koji protein utječe na crijevni imunološki sustav može koristiti kao smjer istraživanja i konačno otvoriti put razvoju novih metoda za liječenje upalnih bolesti crijeva. Relevantni rezultati istraživanja objavljeni su u online izdanju posljednjeg broja časopisa Journal of imunology.
Inflammatory bowel disease refers to ulcerative colitis and Crohn's disease. This disease is common in western countries, and the prevalence rate in China has also begun to rise sharply in recent years. The etiology of inflammatory bowel disease is still unclear, but most studies have targeted the intestinal immune system. A large number of bacteria are parasitic in the human intestine, which plays an important role in maintaining human health. Under normal circumstances, the intestinal immune system will not respond to the activities of beneficial bacteria in the intestine, but only play a role when the internal balance is destroyed. The intestinal immune system of patients with inflammatory bowel disease is different. It will make an immune response to the beneficial flora in the intestine, leading to chronic inflammation.
In a research project funded by the British Medical Research Council and the Wellcome foundation, the research team led by Professor Graham Lord of King's College London found that a protein called T-bet has a strong influence on the interaction between cells of the intestinal immune system. The deletion of this protein will lead to the dysfunction of immune cells, cause inflammation and eventually lead to the occurrence of inflammatory bowel disease. Experiments have proved that once the T-bet protein in the mouse immune system is removed, it will lead to the symptoms similar to human inflammatory bowel disease in mice; Using these proteins as therapeutic targets can reverse the symptoms of inflammatory bowel disease in mice.
Istraživači su istaknuli da je njihovo istraživanje od velikog značaja za potvrdu imunoloških stanica i molekularnih procesa koji po prvi put mogu dovesti do upalnih bolesti crijeva; Poboljšanje T-bet proteina
